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Hormone replacement therapy (HRT) generally means medications containing hormones to replace the ones that body no longer or less produce in patients. This is due to the primary failure of development of the organ (e.g., the ovaries, or testis), premature menopause, castration, or menopause.

Hormones are chemicals that are produced in an organ or gland and then are carried by the blood to another part of the body where they produced a special effect for which they designed (in the target organ).